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The first study to formally evaluate methylation and redox capacity in ASD reported significantly lower plasma levels of methionine, SAM, homocysteine, cystathionine, cysteine, and total GSH, and significantly higher concentrations of S-adenosylhomocysteine (SAH), adenosine, and oxidized GSH (GSSG) in 20 children with ASD compared to 33 controls

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Stress increases voluntary alcohol intake, but does not alter established drinking habits in a rat model of posttraumatic stress disorder